![]() ![]() Few laboratories worldwide have robust qRT-PCR, and even fewer have access to international standardization allowing them to report results on the international scale. ![]() As the authors acknowledge, the completeness of MR is dependent on the assay sensitivity. Readers may be familiar with a popular children’s game called Bop It!, in which players are encouraged to “twist it” and “spin it.” We should be careful to avoid the “spin” that might ensue from this report. BCR-ABL1 DNA was identified in all the evaluable patients in TFR, suggesting that this test is not predictive for the ability to remain off treatment and that mechanisms other than direct inhibition of Bcr-Abl1 are responsible for continuing remission. This group previously investigated the role of patient-specific BCR-ABL1 DNA PCR 5 in identifying residual disease in patients with transcripts undetectable by qRT-PCR. qRT-PCR for bone marrow offered no advantage over qRT-PCR for peripheral blood with respect to predicting or identifying early relapse, another welcome finding. Fifteen of the 22 patients who relapsed did so within 6 months, and all relapsing patients responded promptly with similarly deep MRs on reintroduction of imatinib (see figure), a reassuring fact for any patient contemplating treatment cessation. The primary end point of treatment-free remission (TFR) at 2 years was met by 47% of the patients. (Yes, you should make a reservation, and you should do so in advance.Eligibility criteria were similar to those in STIM, with a minimum of 3 years of imatinib and a minimum of 2 years of UMRD. The dress code here is “fashionable attire,” but the space just makes you want to look nice, without having to be told. Chandeliers wear shimmering fringed skirts, and columns are topped with gold palm leaves. The decor is lush, classic supper club put through a modern filter, all peacock swirls and gleaming golds, with dark leather, rich wood, and crushed velvet wall curtains. Grace by Nia is 5,000 square feet, but it feels intimate, carved into several different spaces: a long bar, standing room only at this hour the stage, fronted by an array of chairs and small round tables just the right size to hold two drinks and two plates, with a banquette and more tables alongside for lounging a dining area away from the entertainment, for those who just want to focus on their food. Grace by Nia is part of the shift.Ĭreole seafood gumbo, a roux-based stew with shrimp, crawfish, chicken, sausage, and okra over rice at Grace by Nia in the Seaport. But between some intentional planning by developers and the tendency of the human spirit to ooze through small cracks, that is starting to change. Soul, character, and diversity are harder to find. Office towers and luxury housing are everywhere in the glossy Seaport neighborhood. ![]() Grace also owns Darryl’s Corner Bar & Kitchen, serving food and live music on the border of the South End and Grace’s native Roxbury. It is the latest project from namesake impresario Nia Grace, in partnership with entertainment and hospitality group Big Night. Grace by Nia - part restaurant, part nightclub, all vibe - opened this month. Acquaintances run into one another: “Well well well! Is this your first time?” The friendliness extends among strangers, too, and the staff works the room shaking hands. The bar is jam-packed, with men in button-downs and fleece vests, women in going-out dresses and towering heels, and everyone and anyone in between - all ages, colors, and fashion senses - drinking cocktails and moving their hips side by side. “I love music! I love it,” she says to no one in particular. ![]() When the saxophone player eases into a solo, a woman in a black-and-white jacket with bright red hair begins dancing, arms in the air, pure joy on her face. Is this really the Seaport - the neighborhood a Globe Spotlight story once referred to as “a brand new Boston, even whiter than the old”? Onstage, a singer is channeling Chaka Khan against a backdrop of curtains lit up blue and purple, the name of the venue - Grace by Nia - illuminated in white and turquoise neon. ![]()
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